Research Methods

A group of rats was divided into groups, and all of their femurs were surgically fractured. Each group received different treatment.

One group received THC, the psychoactive compound in cannabis. Another group received CBD or cannabidiol; while not psychoactive, CBD is another cannabinoid.

The third and final group received just a saline solution. The progress of their bones’ healing processes was then recorded.

Results

The researchers explain that fractures of the type made in rats heal through the formation of a callus that provides the first bridge over the fracture gap.

This callus acts as a scaffolding upon which the bone can begin to form. As the bone begins the grow over the gap, the callus becomes unnecessary and begins to shrink to make way for the incoming bone.
Four weeks after the fracture, the size of the callus was recorded in the three groups of mice. In those groups treated with THC or CBD, the callus was 26% smaller than the group treated with the saline solution.

In other words, the THC and CBD groups were healing faster than the saline group. Further. the CBD group had a roughly 50% stronger femur than the other groups at eight weeks after the fracture.

Implications

The researchers note that fractures of this type are extremely common, affecting people of all ages around the world. As such, the impact of the study are far-reaching and of potential benefit to virtually every person.

The study suggest that CBD, in particular is an extremely effective treatment for bone fractures, as evidenced by both their ability to begin healing the bone more quickly, and increasing its strength later in the healing process.

In healing the bone more quickly, CBD acts not only as a treatment for the break itself, but also for the stiffness, pain, and discomfort associated with breaks of this type.

Importantly, the study ends with authors stating that CBD is a safe compound in humans, and is very well tolerated; in short, there are virtually no risks in administering it as a treatment for fractures.

The Last Hit

Research into cannabis as a treatment for bone fractures is extremely new. The authors made it clear that trials ought to be conducted on humans to test the efficacy of cannabis, and specifically CBD, on helping to heal breaks. If clinical trials of this type prove to be as successful on people as it was on rats, then we may soon see CBD become a staple in treating bone fractures in the future.

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Cannabinoids are also separated into subclasses. These are as follows:

• Cannabigerols (CBG).
• Canabichromenes (CBS).
• Cannabidoils (CBD).
• Tetrahydrocannabinols.
• Cannabinol CBN and Cannabinodiol (CBDL).
• Other cannabinoids such as cannabicyclol (CBL),cannabielson(CBE), cannabitriol (CBT) and other miscellaneous types.

What do cannabinoids do?

Like opiates, cannabinoids affect the user by interacting with specific receptors, located within different parts of the central nervous system. There are only two kinds of cannabinoid receptors that have have been found to do and are termed CB1 and CB2. A substance that occurs naturally in the brain and binds to CB1 receptors was discovered in 1992 and termed “anandamide.”

Additinally natural occuring substances that bind CB1 have since been discovered, and these, together with the receptors are termed the “endogenous cannabinoid system.”

The actual effects that the cannabinoids have reflect the areas of the brain thet interact with. These interactions tend to occur in our limbic syste (the part of the brain that affects memory, cognitions and psychomotor performance) and mesolimbic pathway (activity in this region is associated with feelings of reward) and there are also widely distributed in areas of pain perception.

Many researchers are still learning about the endogenous cannabinoid system. Much of the research however, has focused on the many potential medical uses of man-made cannabioids, refereed to as “synthetic analogues.”

The difference between cannabinoids

The major difference between the cannabinoids are determined by the extent to which they are psychologically active. Three classes of cannabinoids; the CBG, CBC and CBD are not known to have such an effects/ THC, CBN, CBDL and some cannabinoids on the other hand are known to be psychologically active to varying degrees.

CBS is considered tp be the most abundant cannabinoid, contributing up to 40% of cannabis resin. Interestingly, CBD may actually have anti-anxiety effects and lessen the psychoactive effects of THC. This means that a plant with a greater percentage of CBD may reduce the intensity of the effects of the THC, which in effect lowers the potency of the plant. This means that a plant containing less CBD might have an increased psychological impact and result in unwanted effects such as anxiety.

When THC is exposed to air, it oxidizes and forms CBN. CBN is a very weak psychoactive and not unlike CBD interacts with THC to reduce its effects.

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Facts about cannabidiol

CBD is a key ingredient in cannabis

Cannabidiol is one of over 80 compounds found in cannabis that belongs to a class of molecules called cannabinoids. Of these compounds, CBD and THC are usually present in the highest concentrations, and are therefore the most recognized and studied.

CBD and THC levels tend to vary among different plants. Marijuana that’s grown for recreational purposes often contains more THC than CBD.

By using selective breeding techniques, cannabis breeders have managed to create varieties with high levels of CBD and next to zero levels of THC. These strains are rare but they have become more popular.

CBD is non-psychoactive

Unlike THC, CBD does not cause users to get high. While this makes CBD a poor choice for recreational users, it gives the chemical a huge advantage as a medicine, since health professionals prefer treatments with minimal side effects.

CBD is a non-psychoactive because it does not act on the same pathways as THC. These pathways, called CB1 receptors, are highly concentrated in the brain and they are responsible for the mind-altering effects of THC.

CBD has a wide range of medical benefits

Although CBD and THC act on different pathways of the body, they seem to have many of the same benefits.

CBD reduces the negative effects of THC.

CBD seems to offer natural protection against the marijuana high. Numerous studies suggest that CBD acts to reduce the intoxicating effects of THC, such as memory impairment and paranoia.
It also appears to counteract the sleep-inducing effects of THC, which may explain why some strains of cannabis are known to increase alertness.

Both CBD and THC have been found to present no risk of lethal overdose. To reduce potential side effects, medical users may be better off using cannabis with higher levels of CBD.

CBD is sill illegal

Even though CBD shows much promise as a medicine, it remains illegal in many parts of the world. Classified as a Schedule I drug in the United States and a Schedule II drug in Canada.

On the other hand, the FDA recently approved a request to trial a pharmaceutical version of CBD in children with rare forms of epilepsy. The drug is made by GW Pharmaceuticals and is called Epidiolex.

According to the company, the drug consist of “more than 98 percent CBD, trace quantities of some other cannabinoids, and zero THC.” GW Pharmaceuticals makes another cannabis-based drug called Sativex, which has been approved in over 24 countries for treating multiple sclerosis.

A patent awarded to the U.S. Health and Human Services in 2003 (US6630507) also covers the use of CBD as a treatment for various neurodegenerative and inflammatory disorders.

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1. Marijuana slows and stops cancer cells from spreading.

Found in the study, published in the journal of Molecular Cancer Therapeutics, it was found that Cannabidoil has the ability to stop cancer by turning off a gene called Id-1. In 2007, researchers at California Pacific Medical Center in San Francisco, reported that CBD may prevent cancer from spreading. They used cannabidoil to experiment on breast cancer cells in the lab that had a high level of Id-1. The outcome was positive, the cells had decreased Id-1 expression, and they were less aggressive spreaders.

On another note, the American Association for Cancer Research has found that marijuana actually works to slow down tumor growth in the brain, breast, and lungs, considerately.

2. It prevents Alzheimer’s disease

A 2006 study led by Kim Janda of the Scripps Research Institute found out that THC, the active ingredient in marijuana, slows the progression of Alzheimer’s disease. THC slows the formation of amyloid plaques by blocking the enzyme in the brain that makes them. These plaques kill the brain cells, potentially leading to Alzheimer’s disease

3. Treats Glaucoma

Pot can be used to treat a condition known as glaucoma, which increases the pressure in the eyeball, injuring the optic nerve and causing loss of vision. The National Eye Institute has found that marijuana lowers the pressure inside the eye, “Studies in the early 1970s showed that marijuana, when smoked, lowered intraocular pressure (IOP) in people with normal pressure and those with glaucoma.”

The effects of using marijuana can prevent blindness

3.Relieves Arthritis

In 2011, researchers reported that cannabis reduces pain and inflammation, and promotes sleep, which may help relieve pain and discomfort for people suffering from rheumatoid arthritis.

Researchers of the rheumatology units at several hospitals gave their patients Sativex, a cannabinoid-based pain-relieving medicine. After two weeks, they found that patients on Sativex had a significant reduction in pain, and improved sleep quality compared to placebo users.

4. Controls Epileptic seizure

A 2003 study has indicated that the use of marijuana can control epileptic seizures.

Rober J. DeLorenzo, of Virginia Commonwealth University, gave marijuana extract and synthetic marijuana to epileptic rats. The drugs stopped the seizures in about 10 hours. It is fond out that the THC controlled the seizures by binding the brain cells responsible for controlling excitability and regulating relaxation. These results were published in the Journal of Pharmacology and Experimental Therapeutics.

5. Eases the pain of multiple sclerosis

Cannabis works to stop the negative neurological effects and muscle spasms caused by multiple sclerosis. A study published in the Canadian Medical Association suggests that using marijuana may ease painful symptoms of multiple sclerosis.

Jody Cory Bloom studied 30 multiple sclerosis patients with painful contractions in their muscles. These patients didn’t respond to other medications, but after smoking marijuana for a few days, they reported that they were indeed in less pain. The THC bonds the receptors in the nerves and muscles to act as a pain reliever.

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It also used in the treatment of Cancer of All types, Neuro-degenerative diseases such as Epilepsy,Alzheimer’s and Parkinson’s disease.

In addition it is being used to treat Arthritis, Diabetes,Leukemia, Osteoporosis, Crohn’s Disease, Insomnia, Migraines, Depression , Asthma, Multiple Sclerosis, Psoriasis, Glaucoma, Burns, Chronic pain, Alzheimer’s Disease, Mutated cells (tumors, polyps, warts), Stroke, High blood Pressure(Hypertension)and many more.

THC oil has been tested at 40% to 65% THC. The oil is made from White Widow strain of Marijuana which is also a hybrid strain that is 60% Indica and 40% Sativa. and many experts believe this may be the strongest marijuana strain in the entire world.

THC Oil has also been used to cure the following ailments especially Cancer of All Types, Arthritis, Diabetes, Leukemia, Osteoporosis, Crohn’s Disease, Insomnia, Migraines, Depression , Asthma, Multiple Sclerosis, Psoriasis, Glaucoma, Burns, Chronic pain, Alzheimer’s Disease, Mutated cells (tumors, polyps, warts),Stroke,High blood Pressure(Hypertension)and many more.

Charlotte’s Web(CBD) is a strain of medical marijuana that is high in cannabidiol (CBD) content but low in THC, ideal for people avoiding the psychoactive “high” effects of THC associated with Recreational Marijuana. It does not get you high as its 0.01% THC and 100% pure CBD.

This strain was named after a little girl name Charlotte in Colorado. She has epilepsy of a sort and she went from 300 seizures a week to one a week. She eats it in food and is now basically cured, leading a normal life thanks to marijuana.

Charlotte’s Web(CBD)has also been used to cure the same ailments as THC Oil and more.

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